Technical Data
034143
COX6B1, CT (COX6B1, COX6B, Cytochrome c oxidase subunit 6B1, Cytochrome c oxidase subunit VIb isoform 1)
Description:
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively.

Applications:
Suitable for use in Western Blot, Immunohistochemistry, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
COX6B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the C-terminal region of human COX6B1.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Lazarou, M., et al. FEBS J. 276(22):6701-6713(2009)
Massa, V., et al. Am. J. Hum. Genet. 82(6):1281-1289(2008)
Sirchia, R., et al. Biol. Chem. 388(5):457-465(2007)
Schmidt, T.R., et al. Gene 286(1):13-19(2002)
Taanman, J.W., et al. Hum. Genet. 87(3):325-327(1991)