Technical Data
034347
CTSD, ID (CTSD, CPSD, Cathepsin D, Cathepsin D light chain, Cathepsin D heavy chain)
Description:
CTSD is a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.

Applications:
Suitable for use in Western Blot, Flow Cytometry, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:50-100
Flow Cytometry: 1:10-50

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGPurified
SizeStorageShippingSourceHost
100ug-20°CBlue IceHumanRabbit
Concentration:
0.25mg/ml
Immunogen:
CTSD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-252 amino acids from the Central region of human CTSD.
Purity:
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Fujita, H., et al. Biochem. Biophys. Res. Commun. 179(1):190-196(1991)
Faust, P.L., et al. Proc. Natl. Acad. Sci. U.S.A. 82(15):4910-4914(1985)
Knight, C.G., et al. Biochem. J. 155(1):117-125(1976)