Technical Data
DDC, NT (DDC, AADC, Aromatic-L-amino-acid decarboxylase, DOPA decarboxylase)
This protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency.

Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry and ELISA. Other applications not tested.

Recommended Dilution:
Western Blot: 1:1000
Immunofluorescence: 1:10-1:50
Immunohistochemistry: 1:50-1:100
Flow Cytometry: 1:10-1:50
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
PabIgGAffinity Purified
200ul-20CBlue IceHumanRabbit
As reported
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 32-61 in the N-terminal region of human DDC, UniProt Accession #P20711.
Purified by Protein A affinity chromatography.
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Recognizes human DDC. Species crossreactivity: mouse
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Kokkinou, I., et al. J. Neuroimmunol. 216 (1-2), 51-58 (2009) : Meda, S.A., et al. Neuroimage (2009) Ishikawa, S., et al. J. Biol. Chem. 284(42):28832-28844(2009) Trevino, L.R., et al. Nat. Genet. 41(9):1001-1005(2009)