Technical Data
034541
DDX11, CT (DDX11, CHL1, CHLR1, KRG2, Probable ATP-dependent RNA helicase DDX11, CHL1-related protein 1, DEAD/H box protein 11, Keratinocyte growth factor-regulated gene 2 protein)
Description:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Applications:
Suitable for use in Western Blot, Flow Cytometry, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-500
Flow Cytometry: 1:10-50

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
DDX11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 826-855 amino acids from the C-terminal region of human DDX11.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Leman, A.R., et al. J. Cell. Sci. 123 (PT 5), 660-670 (2010) :
Farina, A., et al. J. Biol. Chem. 283(30):20925-20936(2008)
Parish, J.L., et al. Mol. Cell 24(6):867-876(2006)
Parish, J.L., et al. J. Cell. Sci. 119 (PT 23), 4857-4865 (2006) :
Vasa-Nicotera, M., et al. Am. J. Hum. Genet. 76(1):147-151(2005)