Technical Data
034571
DEFA3, CT (DEFA3, DEF3, Neutrophil defensin 3, Defensin, alpha 3, HNP-3, HP 3-56, Neutrophil defensin 2, HNP-2)
Description:
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation.

Applications:
Suitable for use in Western Blot, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-500

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
DEFA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-66 amino acids from the C-terminal region of human DEFA3.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
Chen, Q., et al. Anesthesiology 112(6):1428-1434(2010)
Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)
Paslakis, G., et al. Nephron Exp. Nephrol. 115 (4), E96-E100 (2010) :
Rodriguez-Garcia, M., et al. PLoS ONE 5 (2), E9436 (2010) :