Technical Data
034852
DUSP12, ID (DUSP12, Dual specificity protein phosphatase 12, Dual specificity tyrosine phosphatase YVH1)
Description:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.

Applications:
Suitable for use in Western Blot, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-500

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
DUSP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-191 amino acids from the Central region of human DUSP12.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Human, mouse
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Biernacki, M.A., et al. Cancer Res. 70(3):906-915(2010)
Bonham, C.A., et al. J. Biol. Chem. 284(34):22853-22864(2009)
Sharda, P.R., et al. Biochem. J. 418(2):391-401(2009)
Gao, F., et al. Zhonghua Yi Xue Za Zhi 88(32):2250-2253(2008)
Hasstedt, S.J., et al. Ann. Hum. Genet. 72 (PT 2), 163-169 (2008) :