Technical Data
036478
HDAC3, CT (HDAC3, Histone deacetylase 3, RPD3-2, SMAP45)
Description:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq].

Applications:
Suitable for use in Western Blot, Immunohistochemistry, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
HDAC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 382-412 amino acids from the C-terminal region of human HDAC3.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Minamiya, Y., et al. Tumour Biol. 31(5):533-539(2010)
Kim, H.C., et al. Cell. Mol. Life Sci. 67(20):3499-3510(2010)
Yang, Z., et al. Clin. Chem. Lab. Med. (2010) In press :
Kim, T., et al. Psychiatry Res 178(2):266-269(2010)
Adams, H., et al. Expert Opin. Ther. Targets 14(6):577-584(2010)