Technical Data
036518
HERV-FRD, NT (ERVFRD-1, ERVFRDE1, HERV-FRD_6p24.1 provirus ancestral Env polyprotein, Endogenous retrovirus group FRD member 1, Envelope polyprotein, HERV-FRD, Syncytin-2, Surface protein, Transmembrane protein)
Description:
Human endogenous retroviruses (HERVs) make up approximately 8% of the human genome. Although most HERVs are nonfunctional, the HERV-W (ERVWE1; MIM 604659) and HERV-FRD envelope (env) proteins can induce cell-cell fusion when expressed in cells possessing appropriate receptors (Blaise et al., 2003 [PubMed 14557543]).

Applications:
Suitable for use in Western Blot. Other applications have not been tested.

Recommended Dilution:
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Synthetic peptide corresponding to aa79-107 from the N-terminal region of human HERV-FRD (NP_997465), conjugated to KLH. Species sequence homology: monkey
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Recognizes human HERV-FRD.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Vargas, A., et al. J. Mol. Biol. 392(2):301-318(2009) Chen, C.P., et al. Biol. Reprod. 79(5):815-823(2008) Malassine, A., et al. Retrovirology 5, 6 (2008) : Mangeney, M., et al. Proc. Natl. Acad. Sci. U.S.A. 104(51):20534-20539(2007) Malassine, A., et al. Placenta 28 (2-3), 185-191 (2007) :