Technical Data
037468
KIRR3, CT (KIRREL3, KIAA1867, NEPH2, Kin of IRRE-like protein 3, Kin of irregular chiasm-like protein 3, Nephrin-like protein 2)
Description:
KIRR3 is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. Mutations in this gene are associated with mental retardation autosomal dominant type 4 (MRD4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Applications:
Suitable for use in Western Blot, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-500

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
KIRR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 596~626 amino acids from the C-terminal region of human KIRR3.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Davila, S., et al. Genes Immun. (2010) In press :
Anney, R.J., et al. Am. J. Med. Genet. B Neuropsychiatr.Genet. 147B (8), 1369-1378 (2008)
Bhalla, K., et al. Am. J. Hum. Genet. 83(6):703-713(2008)
Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Sellin, L., et al. FASEB J. 17(1):115-117(2003)