Technical Data
037547
KLHL12, CT (KLHL12, C3IP1, Kelch-like protein 12, CUL3-interacting protein 1, DKIR homolog)
Description:
Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.

Applications:
Suitable for use in Western Blot, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-500

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
KLHL12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 375-404 amino acids from the C-terminal region of human KLHL12.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Human, mouse
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)
Rondou, P., et al. J. Biol. Chem. 283(17):11083-11096(2008)
Lim, J., et al. Cell 125(4):801-814(2006)
Angers, S., et al. Nat. Cell Biol. 8(4):348-357(2006)
Uchida, K., et al. Immunology 116(1):53-63(2005)