Technical Data
038200
MARCO, NT (MARCO, SCARA2, Macrophage receptor MARCO, Macrophage receptor with collagenous structure, Scavenger receptor class A member 2)
Description:
MARCO is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.

Applications:
Suitable for use in ELISA, Western Blot, Immunohistochemistry and Flow Cytometry. Other applications have not been tested.

Recommended Dilutions:
Western Blot: 1:1000
Immunohistochemistry (FFPE): 1:50-1:100
Flow Cytometry: 1:10-1:50
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As Reported
Immunogen:
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 13-40 in the N-terminal region of human MARCO, UniProt Accession #Q9UEW3.
Purity:
Purified by Protein A affinity chromatography
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide
Specificity:
Recognizes human MARCO.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Wright, A.K., et al. J. Leukoc. Biol. 86(3):479-489 (2009). 2. Trynka, G., et al. Gut 58(8):1078-1083 (2009). 3. Arredouani, M.S., et al. J. Immunol. 175(9):6058-6064 (2005). 4. Liu, T., et al. J. Proteome Res. 4(6):2070-2080 (2005). 5. Seta, N., et al. Arthritis Rheum. 44(4):931-939(2001)