		Technical Data
039019	NLRP12, NT (NLRP12, NALP12, PYPAF7, RNO, NACHT, LRR and PYD domains-containing protein 12, Monarch-1, PYRIN-containing APAF1-like protein 7, Regulated by nitric oxide)

Description:
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Alternatively spliced transcript variants encoding distinct isoforms have been described but the full-length nature of some of these has not been determined.

Applications:
Suitable for use in Western Blot, Immunohistochemistry, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Affinity Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Human	Rabbit

Concentration:

0.25mg/ml

Immunogen:

NLRP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 182-212 amino acids from the N-terminal region of human NLRP12.

Purity:

Purified by Protein A affinity chromatography.

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Specificity:

Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

Bailey, S.D., et al. Diabetes Care (2010) In press :
Cummings, J.R., et al. Tissue Antigens 76(1):48-56(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Fahy, R.J., et al. Am. J. Respir. Crit. Care Med. 177(9):983-988(2008)
Jeru, I., et al. Proc. Natl. Acad. Sci. U.S.A. 105(5):1614-1619(2008)