Technical Data
039813
PDE8B, ID (PDE8B, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B, Cell proliferation-inducing gene 22 protein)
Description:
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.

Applications:
Suitable for use in Western Blot, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-500

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceMouseRabbit
Concentration:
As reported
Immunogen:
PDE8B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-324 amino acids from the Central region of human PDE8B.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Mouse
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Horvath, A., et al. Thyroid 20(4):363-367(2010)
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Appenzeller, S., et al. Am. J. Hum. Genet. 86(1):83-87(2010)
Shields, B.M., et al. J. Clin. Endocrinol. Metab. 94(11):4608-4612(2009)
Bimpaki, E.I., et al. Eur. J. Endocrinol. 161(1):153-161(2009)