Technical Data
042435
STX1A, NT (STX1A, STX1, Syntaxin-1A, Neuron-specific antigen HPC-1)
Description:
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis.

Applications:
Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
STX1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36~65 amino acids from the N-terminal region of human STX1A.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Yoshida, T., et al. Int. J. Mol. Med. 24(2):233-246(2009)
Hamdan, F.F., et al. Ann. Neurol. 65(6):748-753(2009)
Corominas, R., et al. Neurosci. Lett. 455(2):105-109(2009)
Chen, C.S., et al. J. Biol. Chem. 284(11):6877-6884(2009)
Ramakrishnan, N.A., et al. J. Biol. Chem. 284(3):1364-1372(2009)
Tian, J.H., et al. J. Biol. Chem. 278(28):26265-26274(2003)