Technical Data
042646
TBCC, NT (TBCC, Tubulin-specific chaperone C, Tubulin-folding cofactor C)
Description:
Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.

Applications:
Suitable for use in Western Blot, ELISA

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:100-500

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceMouseRabbit
Concentration:
As reported
Immunogen:
TBCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-49 amino acids from the N-terminal region of human TBCC.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity:
Mouse
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Hage-Sleiman, R., et al. BMC Cancer 10, 135 (2010) :
Nature 447(7145):661-678(2007)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Bartolini, F., et al. J. Biol. Chem. 277(17):14629-14634(2002)
Tian, G., et al. Cell 86(2):287-296(1996)