Technical Data
044440
(25S)-delta7-Dafachronic acid (UPF-1404)
100ug
Molecular Biology Storage: 4C/-20CShipping: Blue Ice
Ligand of DAF-12, an orphan nuclear receptor, that regulates dauer diapause, reproductive development, fat metabolism, and life span (life cycle) in parasitic nematodes. Sterol-derived hormone. Blocks formation of infective larvae in several parasitic nematodes. Inhibits the dauer-promoting activity of DAF-12. Supports the reproductive development.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Stable for at least 2 years after receipt when stored at -20C.

Molecular Formula:
C27H42O3

Molecular Weight:
414.6
Purity: >95% (HPLC)

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans: D.L. Motola, et al.; Cell 124, 1209 (2006)
A Potential Biochemical Mechanism Underlying the Influence of Sterol Deprivation Stress on Caenorhabditis elegans: M.C. Cheong, et al.; JBC 286, 7248 (2011)
Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan: K.J. Dumas, et al.; Dev. Biol. 340, 605 (2010)
A Conserved Endocrine Mechanism Controls the Formation of Dauer and Infective Larvae in Nematodes: A. Ogawa, et al.; Curr. Biol. 19, 67 (2009)
Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes: Z. Wang, et al.; PNAS 106, 9138 (2009)
Indicted: Worms Caught using Steroids: R.B. Beckstead & C.S. Thummel; Cell 124, 1137 (2006) Review


Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.