Technical Data
ACE2:Fc, Recombinant, Human (SARS Receptor, Angiotensin-converting Enzyme 2, ACEH)
Molecular Biology Storage: 4C/-20CShipping: Blue Ice
ACE2 has direct effects on cardiac functions. It is expressed predominantly in vascular endothelial cells of the heart and kidney. ACE2 converts angiotensin I to angiotensin 1-9. ACE2 was also identified as a functional receptor for SARS coronavirus.

Biological Activity:
Hydrolysis of a fluorescent peptide substrate, Mca-Y-V-A-D-A-P-K(Dnp)-OH.

Signal peptide sequence and the extracellular domain of human ACE2 (aa 1-740) are fused at the C-terminus to the Fc portion of human IgG1.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Working aliquots are stable for up to 3 months when stored at -20C.

Molecular Weight:
~120kD (SDS-PAGE)
Source: Human, HEK 293 cells
Purity: >95% (SDS-PAGE)
Concentration: 1mg/ml
Form: Supplied as a liquid from a 0.2um-filtered solution in PBS, pH 7.2.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
Conformational reorganization of the SARS coronavirus spike following receptor binding: implications for membrane fusion: D.R. Beniac, et al.; PLoS One 2, e1082 (2007)

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.