Technical Data
044500
Anacardic acid (2-Hydroxy-6-pentadecylbenzoic acid, 6-Pentadecylsalicylic acid, AA)
5mg
Biochemicals Storage: +4C/+4CShipping: Blue Ice
Potent histone acetyltransferase (HAT) inhibitor. Antibacterial. SUMOylation inhibitor. Lipoxygenase inhibitor. NF-kappaB inhibitor. Anti-tumor compound. Anti-inflammatory. Apoptosis inducer. Antiproliferative.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: +4C
Stable for at least 2 years after receipt when stored at +4C.

CAS Number:
16611-84-0

Molecular Formula:
C22H36O3

Molecular Weight:
348.5
Purity: >98% (NMR)

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
Small molecule modulators of histone acetyltransferase p300: K. Balasubramanyam, et al.; J. Biol. Chem. 278, 19134 (2003)
Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation: Y. Sun, et al.; FEBS Lett. 580, 4353 (2006)
Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus: H. Muroi & I. Kubo; J. Appl. Bacteriol. 80, 387 (1996)
Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate: I. Fukuda, et al.; Chem. Biol. 16, 133 (2009)
Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids: R. Grazzini, et al.; BBRC 176, 775 (1991)
Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis: B. Sung, et al.; Blood 111, 4880 (2008)
Anacardic acid induces caspase-independent apoptosis and radiosensitizes pituitary adenoma cells: S. Sukumari-Ramesh, et al.; J. Neurosurg. Epub ahead of print (2011)
Anacardic acid inhibits estrogen receptor alpha-DNA binding and reduces target gene transcription and breast cancer cell proliferation: D.J. Schultz, et al.; Mol. Cancer Ther. 9, 594 (2010)


Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.