Technical Data
044572
Astaxanthin (Ovoester, NSC635689, 3,3'-Dihydroxy-beta-carotene-4,4'-dione, CCRIS 7118, HSDB 7468)
5mg
Biochemicals Storage: 4C/-20CShipping: Blue Ice
Potent antioxidant carotenoid. Free radical scavenger. Reduces oxidative stress. Anticancer compound. Anti-inflammatory. Blocks NF-kappaB activatin. Anti-hypertensive. Cardiovascular protective. Improves neuronal stem cell potential. Neuroprotective. Inhibits tumor invasion. Apoptosis inducer. Increases insulin sensitivity. Attenuates diabetes associated coagulatory, oxidative and inflammatory stress PPAR-alpha agonist and PPAR-gamma antagonist. Shows positive effects on obesity and insulin resistance. Hepatoprotective.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Stable for at least 2 years after receipt when stored at -20C.

CAS Number:
472-61-7

Molecular Formula:
C40H52O4

Molecular Weight:
596.80
Purity: >98%

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
Antioxidant activities of astaxanthin and related carotenoids: Y.M. Naguib; J. Agric. Food Chem. 48, 1150 (2000)
Antitumor activity of astaxanthin and its mode of action: H. Jyonouchi, et al.; Nutr. Cancer 36, 59 (2000)
Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation: S.J. Lee, et al.; Mol. Cells 16, 97 (2003)
Antihypertensive potential and mechanism of action of astaxanthin: II. Vascular reactivity and hemorheology in spontaneously hypertensive rats: G. Hussein, et al.; Biol. Pharm. Bull. 28, 967 (2005)
Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease: F.J. Pashkow, et al.; Am. J. Cardiol. 101, 58D (2008) (Review)
Astaxanthin, oxidative stress, inflammation and cardiovascular disease: R.G. Fassett & J.S. Coombes; Future Cardiol. 5, 333 (2009) (Review)
Astaxanthin Improves Stem Cell Potency via an Increase in the Proliferation of Neural Progenitor Cells: J.H. Kim, et al.; Int. J. Mol. Sci. 11, 5109 (2010)
Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans: J.S. Park, et al.; Nutr. Metab. (Lond). 7, 18 (2010)
Astaxanthin improves the proliferative capacity as well as the osteogenic and adipogenic differentiation potential in neural stem cells: J.H. Kim, et al.; Food Chem. Toxicol. 48, 1741 (2010)
Neuroprotective effect of astaxanthin on H(2)O(2)-induced neurotoxicity in vitro and on focal cerebral ischemia in vivo: Y.P. Lu, et al.; Brain Res. 1360, 40 (2010)
Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2: P. Nagendraprabhu & G. Sudhandiran; Invest. New Drugs. 29, 207 (2011)
High dose astaxanthin lowers blood pressure and increases insulin sensitivity in rats: are these effects interdependent?: H.G. Preuss, et al.; Int. J. Med. Sci. 8, 126 (2011)
Ameliorative effect of astaxanthin on endothelial dysfunction in streptozotocin-induced diabetes in male rats: Z.W. Zhao, et al.; Arzneimittelforschung 61, 239 (2011)
Astaxanthin induces mitochondria-mediated apoptosis in rat hepatocellular carcinoma CBRH-7919 cells: X.D. Song, et al.; Biol. Pharm. Bull. 34, 839 (2011)
Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential: P. Kidd; Altern. Med. Rev. 16, 355 (2011) (Review)
Astaxanthin: a potential therapeutic agent in cardiovascular disease: R.G. Fassett & J.S. Coombes; Mar. Drugs 9, 447 (2011) (Review)
Anticoagulatory and antiinflammatory effects of astaxanthin in diabetic rats: K.C. Chan, et al.; J. Food Sci. 77, H76 (2012)
Astaxanthin Treatment Reduced Oxidative Induced Pro-Inflammatory Cytokines Secretion in U937: SHP-1 as a Novel Biological Target: L. Speranza, et al.; Mar. Drugs 10, 890 (2012)
The natural carotenoid astaxanthin, a PPAR-a agonist and PPAR-g antagonist, reduces hepatic lipid accumulation by rewiring the transcriptome in lipid-loaded hepatocytes: Y. Jai, et al.; Mol. Nutr. Food Res. 56, 878 (2012)
Astaxanthin functions differently as a selective peroxisome proliferator-activated receptor g modulator in adipocytes and macrophages: M. Inoue, et al.; Biochem. Pharmacol. (Epub ahead of print) (2012)
Hepatoprotective potential of astaxanthin against 2,3,7,8-tetrachlorodibenzo-p-dioxin in cultured rat hepatocytes: H. Turkez, et al.; Toxicol. Ind. Health. (Epub ahead of print) (2012)

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.