Technical Data
044595
BAY 58-2667 hydrochloride
1mg
Biochemicals Storage: 4C/-20CShipping: Blue Ice
Nitric oxide (NO)- and heme-independent soluble guanylyl cyclase activator. Shows potent cardiovascular effects. Improves cardiopulmonary hemodynamics in patients with acute decompensated heart failure. Exhibits potent vasodilator and antiplatelet activity. Anti-aggregating agent.

Solubility:
Soluble in DSMO

Storage and Stability:
Lyophilized powder may be stored at -20C. Stable for 12 months after receipt at -20C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

CAS Number:
1240669-95-7

Molecular Formula:
C36H39NO5.HCl

Molecular Weight:
602.1
Purity: ~98% (NMR)
Form: Supplied as a white solid

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. J.P. Stasch, et al.; Br. J. Pharmacol. 136, 773 (2002). 2. P. Schmidt, et al.; Eur. J. Pharmacol. 468, 167 (2003). 3. G. Boerrigter & JC. Burnett Jr.; Cardiovasc. Drug Rev. 25, 30 (2007) (Review). 4. R. Frey, et al.; J. Clin. Pharmacol. 48, 1400 (2008). 5. T. Krieg, et al.; Eur. Heart J. 30, 1607 (2009). 6. H. Lapp, et al.; Circulation 119, 2781 (2009). 7. V. Mitrovic, et al.; Heart Fail. Rev. 14, 309 (2009) (Review). 8. J. Tamargo, et al.; Curr. Opin. Investig. Drugs 11, 1039 (2010). 9. S. Roger, et al.; Vascul. Pharmacol. 53, 281 (2010). 10. K. Gtz, et al.; Circ. Res. in press (2014).

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.