Technical Data
Bisindolylmaleimide III (BIM III)
Biochemicals Storage: 4C/-20CShipping: Blue Ice
Potent and selective protein kinase C (PKC) inhibitor. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2).

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Stable for at least 2 years after receipt when stored at -20C. Store solutions at -20C in the dark.

Molecular Formula:

Molecular Weight:
Purity: >98% (NMR)

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C: D. Toullec, et al.; J. Biol. Chem. 266, 15771 (1991)
Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides: P.D. Davis, et al.; J. Med. Chem. 35, 177 (1992)
Protein kinase C inhibitors; structure-activity relationships in K252c- related compounds: S. Fabre & M. Prudhomme; Bioorg. Med. Chem. 1, 193 (1993)
Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors: D. Brehmer, et al.; Mol. Cell Proteomics 3, 490 (2004)
An immuno-chemo-proteomics method for drug target deconvolution: C. Saxena, et al.; J. Proteome Res. 7, 3490 (2008)

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.