Technical Data
Bisindolylmaleimide XI Hydrochloride (Ro 32-0432, BIM XI)
Biochemicals Storage: 4C/-20CShipping: Blue Ice
Selective cell permeable protein kinase C (PKC) inhibitor. G protein-coupled receptor kinase (GRK-5) inhibitor. Less potent GRK-2 or GRK-3 inhibitor. Prevents T cell-driven chronic inflammatory responses in vivo.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Stable for at least 2 years after receipt when stored at -20C. Store solutions at -20C in the dark.

CAS Number:

Molecular Formula:
C28H28N4O2 . HCl

Molecular Weight:
Purity: >98 (HPLC)

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation: A.M. Birchall, et al.; J. Pharmacol. Exp. Ther. 268, 922 (1994)
Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C: S.E. Wilkinson, et al.; Biochem. J. 294, 335 (1993)
Protein kinase C in the treatment of disease: signal transduction pathways, inhibitors, and agents in development: P.G. Goekjian & M.R. Jirousek; Curr. Med. Chem. 6, 877 (1999) (Review)
Involvement of G protein-coupled receptor kinase-6 in desensitization of CGRP receptors: N. Aiyar, et al.; Eur. J. Pharmacol. 403, 1 (2000)

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.