Curcumin (BRN 2306965, CCRIS 3257, NSC 32982, NSC 687842, CI 75300)
|Biochemicals||Storage: 4°C/-20°CShipping: Blue Ice|
Anti-cancer compound. Interferes with multiple cell signaling pathways, including cell cycle (cyclin D1 and cyclin E), apoptosis (activation of caspases and down-regulation of anti-apoptotic gene products), proliferation (HER-2, EGFR and AP-1), survival (PI3K/AKT pathway), invasion (MMP-9 and adhesion molecules), angiogenesis (VEGF), metastasis (CXCR-4) and inflammation (NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX). Anti-angiogenic. Anti-metastatic. Anti-invasive. Chemopreventive. Hedgehog signaling (Hh) modulator. Downregulates Shh and Gli1.
Antioxidant. Anti-inflammatory. Potent inhibitor of NF-kappaB, cyclooxygenase-2 (COX-2), lipooxygenase (LOX), and inducible nitric oxide synthase (iNOS; NOSII). Downregulates the expression of various proinflammatory cytokines including TNF, IL-1, IL-2, IL-6, IL-8, IL-12 and chemokines.
Potent immunomodulator. Modulates several key transcription factors. Down-regulate transcription factors NF-kappaB, AP-1 and Egr-1. Down-regulates the expression of COX-2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1. Down-regulate growth factor receptors (such as EGFR and HER2) and inhibits the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases.
Neuroprotective. Anti-amyloid activity.
Cardioprotective. p300/CBP-HAT inhibitor. Regulates lipid metabolism and downregulates obesity. Activates peroxisome proliferator-activated receptor-gamma (PPARgamma) and Nrf2 cell-signaling pathways. Antiviral, antibacterial, antifungal. Epigenetic agent. Interacts with histone deacetylases (HDACs), histone acetyltransferases (HATs), DNA methyltransferase I and microRNAs.
Storage and Stability:
Short-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 2 years after receipt when stored at -20°C.
Purity: >98% (HPLC)
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Anticancer potential of curcumin: preclinical and clinical studies: B.B. Aggarwal, et al.; Anticancer Res. 23, 363 (2003) (Review)
Curcumin: the story so far: R.A. Sharma, et al.; Eur. J. Cancer 41, 1955 (2005) (Review)
Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases: S. Bengmark; JPEN J. Parenter. Enteral. Nutr. 30, 45 (2006) (Review)
Multiple biological activities of curcumin: a short review: R.K. Maheshwari, et al.; Life Sci. 78, 2081 (2006) (Review)
"Spicing up" of the immune system by curcumin: G.C. Jagetia & B.B. Aggarwal; J. Clin. Immunol. 27, 19 (2007) (Review)
Curcumin: the Indian solid gold: B.B. Aggarwal, et al.; Adv. Exp. Med. Biol. 595, 1 (2007) (Review)
Antioxidant and anti-inflammatory properties of curcumin: V.P. Menon & A.R. Sudheer; Adv. Exp. Med. Biol. 595, 105 (2007) (Review)
Modulation of transcription factors by curcumin: S. Shishodia, et al.; Adv. Exp. Med. Biol. 595, 127 (2007) (Review)
Antitumor, anti-invasion, and antimetastatic effects of curcumin: G. Kuttan, et al.; Adv. Exp. Med. Biol. 595, 173 (2007) (Review)
Curcumin as an inhibitor of angiogenesis: S.S. Bhandarkar & J.L. Arbiser; Adv. Exp. Med. Biol. 595, 185 (2007) (Review)
Neuroprotective effects of curcumin: G.M. Cole, et al.; Adv. Exp. Med. Biol. 595, 197 (2007) (Review)
Immunomodulation by curcumin: S.C. Gautam, et al.; Adv. Exp. Med. Biol. 595, 321 (2007) (Review)
Curcumin and cancer: an "old-age" disease with an "age-old" solution: P. Anand, et al.; Cancer Lett. 267, 133 (2008) (Review)
Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases: B.B. Aggarwal & K.B. Harikumar; Int. J. Biochem. Cell Biol. 41, 40 (2009) (Review)
The protective role of curcumin in cardiovascular diseases: W. Wongcharoen & A. Phrommintikul; Int. J. Cardiol. 133, 145 (2009) (Review)
REVIEW: Curcumin and Alzheimer's disease: T. Hamaguchi, et al.; CNS Neurosci. Ther. 16, 285 (2010) (Review)
Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals: B.B. Aggarwal; Annu. Rev. Nutr. 30, 173 (2010) (Review)
Development of curcumin as an epigenetic agent: S. Fu & R. Kurzrock; Cancer 116, 4670 (2010) (Review)
The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer: F.H. Sarkar, et al.; Cancer Metastasis Rev. 29, 383 (2010) (Review)
Curcumin and obesity: evidence and mechanisms: L. Alappat & A.B. Awad; Nutr. Rev. 68, 729 (2010) (Review)
Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment: P. Basnet & N. Skalko-Basnet; Molecules 16, 4567 (2011) (Review)
Curcumin: a potential neuroprotective agent in Parkinson's disease: R.B. Mythri & M.M. Bharath; Curr. Pharm. Des. 18, 91 (2012) (Review)