Technical Data
044795
FGF-19, Recombinant, Human (His) (Fibroblast Growth Factor 19)
10ug
Molecular Biology Storage: 4C/-20CShipping: Blue Ice
FGF-19 (Fibroblast growth factor 19) is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. FGF-19 plays an important role in brain development during embryogenesis. FGF-19 binds only to FGF receptor 4 (FGFR4). Activity requires the presence of KLB.

Biological Activity:
Activates ERK and FRS2alpha phosphorylation in rat hepatoma cells.

Sequence:
Signal peptide and human FGF-19 (aa 1-216) are fused at the C-terminus to a His-tag.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Working aliquots are stable for up to 3 months when stored at -20C.

Molecular Weight:
~28kD (SDS-PAGE)
Source: Human, HEK 293 cells
Purity: >90% (SDS-PAGE)
Concentration: 0.3mg/ml
Form: Supplied as a liquid from a 0.2um-filtered solution in PBS, pH 7.2.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.