Technical Data
FGF-23, Recombinant, Human (His) (Fibroblast Growth Factor 23, Tumor-derived Hypophosphatemia-inducing Factor)
Growth Factors, Cytokines Storage: 4C/-20CShipping: Blue Ice
FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).

Biological Activity:
Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells.

Signal peptide and human FGF-23 (aa 1-251) are fused at the C-terminus to a His-tag.

Molecular Weight:
~35kD (SDS-PAGE, full-length). FGF23 is cleaved between arg179 and ser 180 (~20kD).

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Working aliquots are stable for up to 3 months when stored at -20C.

Molecular Weight:
~35kD (SDS-PAGE, full-length)
Source: Human, HEK 293 cells
Purity: >90% (SDS-PAGE)
Form: Supplied as a liquid from a 0.2um-filtered solution in PBS, pH 7.2.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.