Technical Data
GANT61 (NSC 136476, 2,2'-((Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl)bis(methylene))bis(N,N-dimethyl)-benzenamine)
Biochemicals Storage: 4C/-20CShipping: Blue Ice
Cell permeable GLI antagonist. Inhibits Gli1 and Gli2-induced transcription. Hedgehog (Hh) signaling pathway inhibitor, downstream of SMO and SUFU. Displays antiproliferative and antitumor activity in vitro and in vivo. Apoptosis inducer.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Stable for at least 2 years after receipt when stored at -20C.

CAS Number:

Molecular Formula:

Molecular Weight:
Purity: >98%

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists: M. Lauth, et al.; PNAS 104, 8455 (2007)
Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells: P. Desch, et al.; Oncogene 29, 4885 (2010)
Hedgehog signaling drives cellular survival in human colon carcinoma cells: T. Mazumdar, et al.; Cancer Res. 71, 1092 (2011)
HH/GLI signalling as a new therapeutic target for patients with oral squamous cell carcinoma. M. Yan, et al.; Oral Oncol. 47, 504 (2011)
Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells: T. Mazumdar, et al.; Cancer Res. (Epub ahead of print) (2011)

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.