Technical Data
044855
GITRL, Soluble, Recombinant, Human (Glucocorticoid-induced TNF Receptor Ligand, AITRL, Activation-inducible TNF-related Ligand, TNFSF18)
50ug
Growth Factors, Cytokines Storage: 4C/-20CShipping: Blue Ice
GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

Sequence:
The extracellular domain of human GITRL (aa 50-177) is fused at the N-terminus to a FLAG-tag.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Working aliquots are stable for up to 3 months when stored at -20C.

Molecular Weight:
~22kD (SDS-PAGE)
Source: Human, HEK 293 cells
Purity: >90% (SDS-PAGE)
Form: Supplied as a lyophilized powder from a 0.2um-filtered solution in PBS, pH 7.2..
Specificity: Binds to human GITR.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.