Technical Data
044898
IGFL3, Recombinant, Human (Insulin Growth Factor-like Family Member 3)
10ug
Growth Factors, Cytokines Storage: 4C/-20CShipping: Blue Ice
Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans (IGFL1 to 4) and one in mice (mIGFL). mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. mIGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 (formerly TMEM-149). Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNF-R family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.

Sequence:
Human IGFL3 (aa 25-125) is fused at the N-terminus to a FLAG-tag.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Stable for at least 6 months after receipt when stored at -20C.

Molecular Weight:
~12kD (SDS-PAGE)
Source: Human, HEK 293 cells
Purity: >95% (SDS-PAGE)
Concentration: 0.1mg/ml
Form: Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
Specificity: Binds to human IGFLR1 (Prod. No. AG-40B-0087).

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1: A.A. Lobito, et al.; J. Biol. Chem. 286, 18969 (2011)


Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.