Technical Data
044900
IGFLR1:Fc, Recombinant, Human (IGF-like Family Receptor 1, Transmembrane Protein 149, TMEM149, U2 Small Nuclear RNA Auxiliary Factor 1-like 4)
50ug
Growth Factors, Cytokines Storage: 4C/-20CShipping: Blue Ice
Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans (IGFL1 to 4) and one in mice (mIGFL). mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. mIGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 (formerly TMEM-149). Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNF-R family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.

Sequence:
Human IGFLR1 (aa 23-154) is fused at the C-terminus to the Fc portion of human IgG1.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Stable for at least 6 months after receipt when stored at -20C.

Molecular Weight:
~50kD (SDS-PAGE)
Source: Human, HEK 293 cells
Purity: >95% (SDS-PAGE)
Concentration: 1mg/ml
Form: Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
Specificity: Binds to its ligand IGFL3 (human) (Prod. No. AG-40B-0090) in the subnanomolar range (< 1ng /ml).

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.