Technical Data
044934
IL-33, Recombinant, Mouse (Interleukin-33, IL-1F11, NF-HEV)
500ug
Growth Factors, Cytokines Storage: -20C/-20CShipping:
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.

Biological Activity:
Activates ST2-dependent NF-kappaB pathway.

Sequence:
Mouse IL-33 (aa 109-266) is untagged.

Storage and Stability:
Short-term Storage: -20C
Long-term Storage: -20C
Stable for at least 6 months after receipt when stored at -20C.

Molecular Weight:
~18kD
Source: Mouse, E. coli
Purity: >95% (SDS-PAGE)
Form: Frozen Contains PBS.
Specificity: Binds to mouse and human ST2.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.