Technical Data
044939
IL-36beta, Recombinant, Human (Interleukin-36beta, Interleukin-1 Family Member 8, IL-1F8)
10ug
Growth Factors, Cytokines Storage: 4C/-20CShipping: Blue Ice
IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.

Sequence:
IL-36beta (human) (aa 5-157) (isoform 2) is untagged.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Stable for at least 6 months after receipt when stored at -20C.

Molecular Weight:
~15kD (SDS-PAGE)
Source: Human, E. coli
Purity: >95% (SDS-PAGE)
Form: Supplied as a lyophilized powder from a 0.2um-filtered solution in PBS, pH 7.2, 0.5% Trehalose.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.