Technical Data
044941
IL-36Ra, Recombinant, Mouse (Interleukin-36 Receptor Antagonist Protein, IL-1F5, Interleukin-1 Family Member 5, IL-1delta, Interleukin-1delta, Interleukin-1 Homolog 3, Interleukin-1-like Protein 1)
10ug
Growth Factors, Cytokines Storage: 4C/-20CShipping: Blue Ice
IL-36Ra/IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are target of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.

Biological Activity:
Inhibits the IL-6 induced expression of IL-36alpha (IL-1F6), IL-36beta (IL-1F8), and IL-36gamma (IL-1F9) in BMDCs. 1ug/ml of IL-36Ra inhibits the activity of 10 ng to 100 ng/ml of the agonists.

Sequence:
IL36Ra (mouse) (aa 2-156) is untagged.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Stable for at least 6 months after receipt when stored at -20C.

Molecular Weight:
~17kD
Source: Mouse, E. coli
Purity: >95% (SDS-PAGE)
Concentration: 0.1mg/ml
Form: Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.