Technical Data
044950
IL-6, Recombinant, Mouse:Fc (Interleukin-6, B Cell Hybridoma Growth Factor, Interleukin HP-1)
10ug
Molecular Biology Storage: 4C/-20CShipping: Blue Ice
Interleukin 6 (IL-6) is a pleiotropic alpha-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22kD-28kD phosphorylated and variably glycosylated molecule. IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6R) and a signal transducing subunit (gp130). IL-6 is a key factor for the growth of plasma cells.

Biological Activity:
Promotes growth of hybridoma/plasma cells at concentration <0.1ng /ml.

Sequence:
The extracellular domain of mouse IL-6 (aa 25-211) is fused at the C-terminus to the Fc portion of human IgG2.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Stable for at least 1 year after receipt when stored at -20C. Working aliquots are stable for up to 3 months when stored at -20C.
Source: Human, Mouse, HEK 293 cells
Purity: >95% (SDS-PAGE)
Concentration: 0.1mg/ml
Form: Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.