Technical Data
044976
Kaempferitrin (Lespenefril, Lespedin, BRN 0073958, Kaempferol 3,7-dirhamnoside)
1mg
Biochemicals Storage: 4C/-20CShipping: Blue Ice
Cytotoxic and anti-inflammatory compound (weak). Antioxidant. Lipid peroxidation inhibitor. Free radical scavenger. Inhibitor of myeloperoxidase activity. Hypoglycemic. Decreases blood glucose levels in diabetic and normal rats. Insulinomimetic. Modulates glucose homeostasis. Decreaes blood glucose levels and stimulates glucose uptake in muscle. Inhibits GLUT4 mediated glucose uptake in differentiated 3T3-L1 cells. Improves insulin resistance by the activation of the classical insulin transduction pathway. Increases adiponectin secretion in 3T3-L1 adipocytes. Antinoniceptive. May have antidyslipidemic activity

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Stable for at least 2 years after receipt when stored at -20C. Store solutions at -20C in the dark.

CAS Number:
482-38-2

Molecular Formula:
C27H30O14

Molecular Weight:
578.5
Purity: >97% (HPLC)

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
Kaempferitrin from the leaves of Hedyotis verticillata and its biological activity: A.S. Hamzah, et al.; Planta Med. 60, 388 (1994)
Hypoglycemic effect and antioxidant potential of kaempferol-3,7-O-(alpha)-dirhamnoside from Bauhinia forficata leaves: E. de Sousa, et al.; J. Nat. Prod. 67, 829 (2004)
Insulinomimetic effects of kaempferitrin on glycaemia and on 14C-glucose uptake in rat soleus muscle: A.P. Jorge, et al.; Chem. Biol. Interact. 149, 89 (2004)
Inhibitory effects of flavonol glycosides from Cinnamomum osmophloeum on inflammatory mediators in LPS/IFN-gamma-activated murine macrophages: S.H. Fang, et al.; Bioorg. Med. Chem. 13, 2381 (2005)
Flavonols from Pterogyne nitens and their evaluation as myeloperoxidase inhibitors: L.O. Regasini, et al.; Phytochemistry 69, 1739 (2008)
Kaempferitrin inhibits GLUT4 translocation and glucose uptake in 3T3-L1 adipocytes: C.N. Vishnu Prasad, et al.; BBRC 380, 39 (2009)
Kaempferitrin activates the insulin signaling pathway and stimulates secretion of adiponectin in 3T3-L1 adipocytes: Y.M. Tzeng, et al.; Eur. J. Pharmacol. 607, 27 (2009)
Antinociceptive and anti-inflammatory kaempferol glycosides from Sedum dendroideum: G.O. De Melo, et al.; J. Ethnopharmacol. 124, 228 (2009)
Antidyslipidemic Activity of Hot-water Extracts from Leaves of Cinnamomum osmophloeum Kaneh: T.Y. Lin, et al.; Phytother. Res. (Epub ahead of print) (2011)
Lotus corniculatus regulates the inflammation induced by bradykinin in a murine model of pleurisy: D.A. Pereira, et al.; J. Agric. Food Chem. 59, 2291 (2011)
Kaempferol and kaempferol rhamnosides with depigmenting and anti-inflammatory properties: H.S. Rho, et al.; Molecules 16, 3338 (2011)
Effects of flavonoids on alpha-glucosidase activity: potential targets for glucose homeostasis: D.F. Pereira, et al.; Nutrition 27, 1161 (2011)


Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.