KN-93 (water soluble) (2-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine)
|Biochemicals||Storage: 4°C/-20°CShipping: Blue Ice|
Selective Ca2+/calmodulin-dependent protein kinase II inhibitor.
Insulin release inhibitor.
Acid secretion inhibitor.
G1 cell cycle arrest inducer.
Ion channel inhibitor.
Androgen receptor inhibitor.
Storage and Stability:
Short-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 2 years after receipt when stored at -20°C.
C26H29ClN2O4S . H3PO4
Purity: >98% (NMR)
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi, et al.; BBRC 181, 968 (1991)
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki, et al.; BBRC& 191, 255 (1993)
Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya, et al.; BBRC 195, 608 (1993)
G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R.M. Tombes, et al.; Cell Growth Differ. 6, 1063 (1995)
CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels: L. Gao, et al.; BBRC 345, 1606 (2006)
KN-93 (2--N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels: S. Reazadeh, et al.; J. Pharmacol. Exp. Ther. 317, 292 (2006)
KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer: O.W. Rokhlin, et al.; Cancer Biol. Ther. 9, 224 (2010)