Technical Data
045038
Monosodium urate (crystals) (MSU (crystals), Uric acid (crystals))
2mg
Biochemicals Storage: -20CShipping: Blue Ice
NLRP3/NALP3 inflammasome activator. Specially crystallized and tested for biological activity. Stimulates the caspase-1 activating NLRP3/NALP3 inflammasome, resulting in the production of active IL-1beta and IL-18.

Appearance:
Solid crystals; Slightly hazy as a solution

Solubility (25mg/ml):
Soluble in PBS or 1M NaOH

Storage and Stability:
May be stored at 4C for short-term only. Long-term storage is recommended at -20C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Vortex before use.

CAS Number:
1198-77-2

Molecular Formula:
C5H3N4O3 . Na

Molecular Weight:
190.1
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
Monosodium urate crystals in inflammation and immunity: Y. Shi, et al.; Immunol. Rev. 233, 203 (2010)
Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 beta by mononuclear cells through a caspase 1-mediated process: E.J. Giamarellos-Bourboulis, et al.; Ann. Rheum. Dis. 68, 273 (2009)
Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases: M.T. Shio, et al.; PLoS Pathog. 5, e1000559 (2009)
Gout-associated uric acid crystals activate the NALP3 inflammasome: F. Martinon, et al.; Nature 440, 237 (2006)


Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.