Technical Data
Notch1 (Biotin) (Neurogenic Locus Notch Homolog Protein 1, Motch A, mT14, p300)
Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.

Suitable for use in Flow Cytometry

Recommended Dilution:
Optimal dilutions to be determined by researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
MabIgG2a,k22E5Highly Purified
100ug4C/-20CBlue IceMouseRat
Recombinant mouse Notch1:Fc (AG-40B-0109).
>95% (SDS-PAGE)
Supplied as a liquid in PBS, 0.02% sodium azide.
Recognizes endogenous mouse Notch-1 receptor.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Product Reference: Dynamic Regulation of Notch 1 and Notch 2 Surface Expression during T Cell Development and Activation Revealed by Novel Monoclonal Antibodies: E. Fiorini, et al.; J. Immunol. 183, 7212 (2009)