Technical Data
Notch1 (Neurogenic Locus Notch Homolog Protein 1, Motch A, mT14, p300)
Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.

Suitable for use in Flow Cytometry

Recommended Dilution:
Optimal dilutions to be determined by researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
MabIgG2a,k22E5Highly Purified
100ug4C/-20CBlue IceMouseRat
Recombinant mouse Notch1:Fc (AG-40B-0109).
>95% (SDS-PAGE)
Supplied as a liquid in PBS, 10% glycerol, 0.02% sodium azide.
Recognizes endogenous mouse Notch-1 receptor.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Product Reference: Dynamic Regulation of Notch 1 and Notch 2 Surface Expression during T Cell Development and Activation Revealed by Novel Monoclonal Antibodies: E. Fiorini, et al.; J. Immunol. 183, 7212 (2009)