Technical Data
045108
NU6102 (O6-Cyclohexylmethyl-2-(4-sulfamoylanilino)purine)
1mg
Biochemicals Storage: 4C/-20CShipping: Blue Ice
Potent CDK1/cyclin B (IC50 = 9.5 nM) and CDK2/cyclin A3 (IC50 = 5.4 nM) inhibitor.
1'000-fold more potent than NU2058.
Selective for CDK1 and CDK2 compared to CDK4/D1 (IC50 = 1.6 M), DYRK1A (IC50 = 0.9 M), PDK1 (IC50 = 0.8 M) and ROCKII (IC50 = 0.6 M).
Inhibits cell growth.


Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Stable for at least 2 years after receipt when stored at -20C.

CAS Number:
444722-95-6

Molecular Formula:
C18H22N6O3S

Molecular Weight:
402.5
Purity: >98% (NMR)

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor: T.G. Davies, et al.; Nat. Struct. Biol. 9, 745 (2002)
N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2: I.R. Hardcastle, et al.; J. Med. Chem.47, 3710 (2004)
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2: K.L. Sayle, et al.; Bioorg. Med. Chem. Lett. 13, 3079 (2003)


Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.