Cell permeable and selective calpain inhibitor. Interacts with calcium-binding domain of calpain. Neuroprotective. Ca2+-permeable AMPA receptor inhibitor. Apoptosis inhibitor
Storage and Stability:
Short-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 2 years after receipt when stored at -20°C.
Purity: >98% (NMR)
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference: |
Modulation of hypoxia-induced calpain activity in rat renal proximal tubules: C.L. Edelstein, et al.; Kidney Int. 50, 1150 (1996)
An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective: K.K. Wang, et al.; PNAS 93, 6687 (1996)
Alpha-mercaptoacrylic acid derivatives as novel selective calpain inhibitors: K.K. Wang, et al.; Adv. Exp. Med. Biol. 389, 95 (1996)
Crystal structure of calcium bound domain VI of calpain at 1.9A resolution and its role in enzyme assembly, regulation, and inhibitor binding: G.D. Lin, et al.; Nat. Struct. Biol. 4, 539 (1997)
An alpha-mercaptoacrylic acid derivative (PD150606) inhibits selective motor neuron death via inhibition of kainate-induced Ca2+ influx and not via calpain inhibition: L. Van den Bosch, et al.; Neuropharmacology 42, 706 (2002)
Calpain, an upstream regulator of thymocyte apoptosis: M.K. Squier & J.J. Cohen; J. Immunol. 158, 3690 (1997)
|Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.|