Potent microtubule assembly inhibitor. Anticancer compound. Cell death inducer. DNA topoisomerase II inhibitor. Cell cycle inhibitor at the metaphase. Antiviral and antihelminthic.
Storage and Stability:
May be stored at 4ºC for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic. Store under inert gas. Protect from moisture.
Source: Synthetic. Originally isolated from Podophyllum peltatum
Purity: 98% (HPLC)
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1.VP16-213 and podophyllotoxin. A study on the relationship between chemical structure and biological activity: J.D. Loike; Cancer Chemother. Pharmacol. 7, 103 (1982) Antitumor agents. I. DNA topoisomerase II inhibitory activity and the structural relationship of podophyllotoxin derivatives as antitumor agents: T. Terada, et al.; Chem. Pharmacol. Bull. (Tokyo) 40, 2720 (1992) Antineoplastic and antiviral activities of podophyllotoxin related lignans: M. Gordaliza, et al.; Arch. Pharmacol. 327, 175 (1994) Podophyllotoxin: C. Canel, et al.; Phytochemistry 54, 115 (2000) (Review) Antitumor properties of podophyllotoxin and related compounds: M. Gordaliza, et al.; Curr. Pharm. Des. 6, 1811 (2000) (Review) Drugs that inhibit tubulin polymerization: the particular case of podophyllotoxin and analogues: S. Desbene & S. Giorgi-Renault; Curr. Med. Chem. Anticancer Agents 2, 71 (2002) (Review) Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents: Y. You; Curr. Pharm. Des. 11, 1695 (2005) (Review) Camptothecin and podophyllotoxin derivatives: inhibitors of topoisomerase I and II - mechanisms of action, pharmacokinetics and toxicity profile: J.T. Hartmann & H.P. Lipp; Drug Saf. 29, 209 (2006) (Review) An evidence-based review of medical and surgical treatments of genital warts: N. Scheinfeld & D.S. Lehman; Dermatol. Online J. 12, 5 (2006)|
|Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.|