Technical Data
045175
Progranulin, Recombinant, Mouse (Proepithelin, PEPI, PC Cell-derived Growth Factor)
10ug
Molecular Biology Storage: 4C/-20CShipping: Blue Ice
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Biological Activity:
Activates ERK phosphorylation in MCF10A cells.

Sequence:
Signal peptide and mouse progranulin (aa 1-589) are fused at the C-terminus to a FLAG-tag.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Working aliquots are stable for up to 3 months when stored at -20C.

Molecular Weight:
~70kD (SDS-PAGE)
Source: Mouse, HEK 293 cells
Purity: >95% (SDS-PAGE)
Concentration: 0.5mg/ml
Form: Supplied as a liquid from a 0.2um-filtered solution in PBS, pH 7.2.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3beta phosphorylation: T. Nedachi, et al.; Neuroscience 185, 106 (2011)


Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.