Technical Data
045184
Pyrin (Marenostrin, MEFV)
Description:
Pyrin regulates inflammation by interacting with the cytoskeleton. Pyrin may direct the migration of white blood cells to sites of inflammation and stop or slow the inflammatory response when it is no longer needed. Defects in pyrin are the cause for Mediterranean fever.

Applications:
Suitable for use in Immunoprecipitation, Western Blot

Recommended Dilution:
Optimal dilutions to be determined by researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabAffinity Purified
SizeStorageShippingSourceHost
100ug4C/-20CBlue IceHumanRabbit
Concentration:
1mg/ml
Immunogen:
Synthetic peptide corresponding to aa 2-29 (A2KTPSDHLLSTLEELVPYDFEKFKFKLQ29) of human pyrin.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, 10% glycerol, 0.02% sodium azide.
Specificity:
Recognizes human pyrin.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Product Reference:
The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing: S. Papin, et al.; Cell Death Differ. 14, 1457 (2007)