Technical Data
SANT-2 (N-3,4,5-triethoxybenzamide)
Biochemicals Storage: 4C/-20CShipping: Blue Ice
Cell permeable potent smoothened (Smo) antagonist. Inhibits wt and oncogenic Smo. Tool to study hedgehog (Hh) signaling pathway. SAG activity inhibitor. Gli1 reporter gene expression inhibitor. Suppresses the Shh-dependent translocation of Smo to the primary cilium. Potential tumor growth blocker.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: -20C
Stable for at least 2 years after receipt when stored at -20C. Store solutions at -20C in the dark.

CAS Number:

Molecular Formula:

Molecular Weight:
Purity: >95% (NMR)

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
Small molecule modulation of Smoothened activity: J.K. Chen, et al.; PNAS 99, 14071 (2002)
Targeting the Hedgehog pathway in cancer: L.L. Rubin & F.J. de Sauvage; Nat. Rev. Drug. Discov. 5, 1026 (2006) (Review)
Evidence for allosteric interactions of antagonist binding to the smoothened receptor: C.M. Rominger, et al.; J. Pharmacol. Exp. Ther. 329, 995 (2009)
Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process: R. Rohatgi, et al.; PNAS 106, 3196 (2009)
Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway: A. Bttner, et al.; Bioorg. Med. Chem. 17, 4943 (2009)

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.