Specific cell permeable SIRT1 (sirtuin-1) inhibitor. Senescence-like growth arrest inducer. Platelet aggregation inhibitor. Apoptosis inducer.
Storage and Stability:
Short-term Storage: +4°C
Long-term Storage: +4°C
Stable for at least 2 years after receipt when stored at +4°C.
Purity: >98% (NMR)
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference: |
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening: C.M. Grozinger, et al.; J. Biol. Chem. 276, 38837 (2001)
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors: A. Mai, et al.; J. Med. Chem. 48, 7789 (2005)
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells: H. Ota, et al.; Oncogene 25, 176 (2006)
A new insight of anti-platelet effects of sirtinol in platelets aggregation via cyclic AMP phosphodiesterase: F.C. Liu, et al.; Biochem. Pharmacol. 77, 1364 (2009)
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2: B. Peck, et al.; Mol. Cancer Ther. 9, 844 (2010)
|Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.|