Technical Data
Stevioside hydrate (BRN 0077427, CCRIS 6116)
Biochemicals Storage: +4C/+4CShipping: Blue Ice
Noncaloric natural sweetener, 300 times more potent than sucrose.
Antidiabetic. Antihyperglycaemic and antihypoglycaemic. Potentiates insulin secretion. Enhances acetyl-CoA carboxylase (ACC) gene expression. Increases insulin sensitivity..
Antihypertensive. Ca2+ influx inhibitor.
Anticancer compound.
Anti-inflammatory. IKKbeta, NF-kappaB and MAPK signaling inhibitor. Induces TNF-alpha, IL-1beta and nitric oxide release.
Immunomodulator. Increasees phagocytic activity, haemagglutination antibody titre, delayed type hypersensitivity. Increased proliferation in LPS and Con A stimulated B and T cells.
Peripheral -opioid receptors activator. Important for regulation of glucose homeostasis.

Storage and Stability:
Short-term Storage: +4C
Long-term Storage: +4C
Stable for at least 2 years after receipt when stored at +4C.

CAS Number:
57817-89-7 (anhy)

Molecular Formula:
C38H60O18 . xH2O

Molecular Weight:
804.9 (anhy)
Purity: >95% (NMR)

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
Letter to the editor: stevioside, a natural sweetening agent: C. Taylor; Am. J. Clin. Nutr. 22, 4 (1969)
Stevioside acts directly on pancreatic beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity: P.B. Jeppesen, et al.; Metabolism 49, 208 (2000)
Inhibitory effect of stevioside on calcium influx to produce antihypertension: C.N. Lee, et al.; Planta Med. 67, 796 (2001)
Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats: P.B. Jeppesen, et al.; Phytomedicine 9, 9 (2002)
Inhibitory effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin: K. Yasukawa, et al.; Biol. Pharm. Bull. 25, 1488 (2002)
Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat: P.B. Jeppesen, et al.; Metabolism 52, 372 (2003)
Antihyperglycemic effects of stevioside in type 2 diabetic subjects: S. Gregersen, et al.; Metabolism 53, 73 (2004)
Effects of stevioside on glucose transport activity in insulin-sensitive and insulin-resistant rat skeletal muscle: N. Lailerd, et al.; Metabolism 53, 101 (2004)
Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana: T.H. Chen, et al.; Planta Med. 71, 108 (2005)
Anti-Inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP-1 Cells: C. Boonkaewwan, et al.; J. Agric. Food Chem. 54, 785 (2006)
Stevioside improves pancreatic beta-cell function during glucotoxicity via regulation of acetyl-CoA carboxylase: J. Chen, et al.; Am. J. Physiol. Endocrinol. Metab. 292, E1906 (2007)
Immune up regulatory response of a non-caloric natural sweetener, stevioside: I. Sehar, et al.; Chem. Biol. Interact. 173, 115 (2008)
Stevioside and related compounds: therapeutic benefits beyond sweetness: V. Chatsudthipong & C. Muanprasat; Pharmacol. Ther. 121, 41 (2009) (Review)
Cancer preventive agents. Part 8: Chemopreventive effects of stevioside and related compounds: M. Takasaki, et al.; Bioorg. Med. Chem. 17, 600 (2009)
Stimulatory effect of stevioside on peripheral mu opioid receptors in animals: P.S. Yang, et al.; Neurosci. Lett. 454, 72 (2009)
Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice: B. Geeraert, et al.; Int. J. Obes. 34, 569 (2010)
Stevioside ameliorates high-fat diet-induced insulin resistance and adipose tissue inflammation by downregulating the NF-kappaB pathway: Z. Wang, et al.; BBRC 417, 1280 (2012)
Stevioside Suppressed Inflammatory Cytokine Secretion by Downregulation of NF-kappaB and MAPK Signaling Pathways in LPS-Stimulated RAW264.7 Cells: L. Fengyang, et al.; Inflammation 35, 1669 (2012)

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.