Technical Data
045328
Terpendole C
250ug
Biochemicals Storage: -20CShipping: Blue Ice
Inhibitor for Acyl-CoA, cholesterol acyltransferase (ACAT) isozymes ACAT1 and ACAT2, Tremorgenic and Cholesteryl ester (CE) synthesis

Solubility:
Soluble in DSMO, ethanol or methanol

Storage and Stability:
Lyophilized powder may be stored at -20C. Stable for 12 months after receipt at -20C. Reconstitute with DSMO, ethanol or methanol. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

CAS Number:
156967-65-6

Molecular Formula:
C32H41NO5

Molecular Weight:
519.70
Purity: ~95% (HPLC)
Form: As reported

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Product Reference:
Microbial metabolites affecting lipid biosynthesis: S. Omura & H. Tomoda; Pure Appl. Chem. 66, 2267 (1994)
Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. I. Production, isolation and biological properties: X.H. Huang, et al.; J. Antibiot. (Tokyo) 48, 1 (1995)
Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. II. Structure elucidation of terpendoles A, B, C and D: X.H. Huang, et al.; J. Antibiot. (Tokyo) 48, 5 (1995)
Isolation and structure elucidation of lolilline, a possible biosynthetic precursor of the lolitrem family of tremorgenic mycotoxins: S.C. Munday-Finch, et al.; J. Agric. Food Chem. 45, 199 (1997)
Terpendole M, a novel indole-diterpenoid isolated from Lolium perenne infected with the endophytic fungus Neotyphodium lolii: W.A. Gatenby, et al.; J. Agric. Food Chem. 47, 1092 (1999)
Selectivity of microbial acyl-CoA:cholesterol acyltransferase inhibitors toward isozymes: T. Ohshiro, et al.; J. Antibiot. (Tokyo) 60, 43 (2007)
Potential therapeutics for obesity and atherosclerosis: Inhibitors of neutral lipid metabolism from microorganisms: H. Tomoda & S. Omura; Pharmacol. Ther. 115, 375 (2007)


Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.