Technical Data
Terpendole E (1'alpha-Hydroxy-Paspaline)
Biochemicals Storage: -20CShipping: Blue Ice
Inhibitor to Acyl-CoA: Cholesterol acyltransferase (ACAT), Mitotic kinesin Eg5 (Mitotic Kinesin Spindle Protein; KSP) and Specific M phase.

Soluble in DMSO, ethanol or methanol

Storage and Stability:
Lyophilized powder may be stored at -20C. Stable for 12 months after receipt at -20C. Reconstitute with DSMO, ethanol or methanol. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

CAS Number:

Molecular Formula:

Molecular Weight:
Source: Albophoma yamanashiensis
Purity: 95% (HPLC)
Form: Supplied as a off-white solid

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Microbial metabolites affecting lipid biosynthesis: S. Omura & H. Tomoda; Pure Appl. Chem. 66, 2267 (1994). 2. Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. I. Production, isolation and biological properties: X.H. Huang, et al.; J. Antibiot. (Tokyo) 48, 1 (1995). 3. A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5: J. Nakazawa, et al.; Chem. Biol. 10, 131 (2003). 4. Development and application of bioprobes for Mammalian cell cycle analyses: H. Osada; Curr. Med. Chem. 10, 727 (2003). 5. Docking studies on kinesin spindle protein inhibitors: an important cooperative 'minor binding pocket' which increases the binding affinity significantly: C. Jiang, et al.; J. Mol. Model 13, 987 (2007). 6. A novel approach to indoloditerpenes by Nazarov photocyclization: synthesis and biological investigations of terpendole E analogues: F. Churruca, et al.; Org. Lett. 12, 2096 (2010). 7. Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds: S. Oishi, et al.; J. Med. Chem. 53, 5054 (2010)

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.