Technical Data
TNF-alpha, Soluble, Recombinant, Human (ACRP30headless:TNF-alpha, ACRP30headless:TNFSF2, ACRP30headless:Tumor Necrosis Factor-alpha)
Molecular Biology Storage: 4°C/-20°CShipping: Blue Ice
Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. MegaTNF-alpha™ is a high activity construct in which two trimeric TNF-alpha ligands are artificially linked via the collagen domain of ACRP30.

Biological Activity:
Activates human and mouse TNF-R1 and TNF-R2.

The extracellular domain of human TNF-alpha (aa 85-233) is fused at the N-terminus to human ACRP30headless (aa 16-108) and a FLAG®-tag.

Storage and Stability:
Short-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Molecular Weight:
~34kD (SDS-PAGE)
Source: Human, HEK 293 cells
Purity: >95% (SDS-PAGE)
Concentration: 0.1mg/ml
Form: Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
Specificity: Binds to human and mouse TNF-R1 and TNF-R2.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.