Technical Data
AKAP7, Recombinant, Human, aa1-81, His-Tag (A-kinase Anchor Protein 7 Isoforms alpha and beta, AKAP-7 Isoforms alpha and beta, Protein Kinase A-anchoring Protein 7 Isoforms alpha/beta, A-kinase Anchor Protein 18kD, AKAP 18, AKAP18)
Molecular Biology Storage: -20CShipping: Blue Ice
AKAP7 (A-kinase anchor protein 7 isoform gamma isoform alpha) , also known as AKAP18, belongs to the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAP 7 is expressed in brain, heart, lung, pancreas and skeletal muscle. AKAP 7 binds PKA to the plasma membrane, and permits functional coupling to the L-type calcium channel.

Recombinant corresponding to aa1-81 from human AKAP7, fused to His-tag at N-terminus, expressed in E.coli.

Molecular Weight:
~11.5kD (105aa) confirmed by MALDI-TOF

AA Sequence:

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight:
Source: E.coli
Purity: ~90% (SDS-PAGE)
Concentration: ~1mg/ml
Form: Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 1mM DTT, 50mM sodium chloride, 10% glycerol.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Trotter K.W., et al. (1999) J. Cell Biol. 147:1481-1492. 2. Klussmann, E., et al. (2001) Kidney Int. 60: 446-449.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.